No. 1
Multimodal Model for Computational Pathology:Representation Learning and Image Compression
TLDR本文综述了多模态计算病理学的最新进展,重点探讨了全切片图像处理、自监督学习、多模态数据生成、高效微调及多智能体推理等方法,旨在解决高分辨率图像计算、标注稀缺、多模态融合及模型可解释性等挑战,以推动可解释、安全的AI辅助诊断发展。
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Abstract
Whole slide imaging (WSI) has transformed digital pathology by enabling computational analysis of gigapixel histopathology images. Recent foundation model advances have accelerated progress in computational pathology, facilitating joint reasoning across pathology images, clinical reports, and structured data. Despite this progress, challenges remain: the extreme resolution of WSIs creates computational hurdles for visual learning; limited expert annotations constrain supervised approaches; integrating multimodal information while preserving biological interpretability remains difficult; and the opacity of modeling ultra-long visual sequences hinders clinical transparency. This review comprehensively surveys recent advances in multimodal computational pathology. We systematically analyze four research directions: (1) self-supervised representation learning and structure-aware token compression for WSIs; (2) multimodal data generation and augmentation; (3) parameter-efficient adaptation and reasoning-enhanced few-shot learning; and (4) multi-agent collaborative reasoning for trustworthy diagnosis. We specifically examine how token compression enables cross-scale modeling and how multi-agent mechanisms simulate a pathologist's "Chain of Thought" across magnifications to achieve uncertainty-aware evidence fusion. Finally, we discuss open challenges and argue that future progress depends on unified multimodal frameworks integrating high-resolution visual data with clinical and biomedical knowledge to support interpretable and safe AI-assisted diagnosis.
Motivation
全切片成像推动了数字病理学发展,但高分辨率图像带来计算负担、专家标注有限、多模态信息融合困难及模型不透明等问题,制约了AI在病理诊断中的应用。本文旨在系统回顾多模态计算病理学的最新方法,以应对这些挑战。
Method
采用文献综述方法,系统分析了四个研究方向:1) 全切片图像的自监督表示学习与结构感知令牌压缩;2) 多模态数据生成与增强;3) 参数高效适应与推理增强的小样本学习;4) 多智能体协同推理以实现可信诊断。重点探讨了令牌压缩实现跨尺度建模,以及多智能体机制模拟病理学家“思维链”进行不确定性感知证据融合。
Result
综述总结了多模态计算病理学在图像处理、数据增强、学习效率和可解释推理等方面的关键技术进展,表明这些方法有助于克服计算瓶颈、减少标注依赖、提升模型透明度和诊断可靠性。
Conclusion
未来进展依赖于构建统一的多模态框架,整合高分辨率视觉数据与临床生物医学知识,以支持可解释、安全的AI辅助诊断。开放挑战包括进一步优化模型效率、增强生物可解释性及确保临床实用性。